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Building Blocks

Key Facts of PharmaBlock Building Blocks

40,000+ building blocks

10,000+ in stock

20,000+ delivered within 2 weeks

1,000+ SAR/SPR tool kits

18 core series featuring industry leadership

60+ chemical series, covering all commenly-used structures in R&D of small molecule drugs 

Why PharmaBlock

Novelty & Diversity

Novel building blocks designed by medicinal chemists upon weekly monitoring on recent research and patents

Price Advantage

Keep optimizing cost-effective synthetic route

Sustainable Supply

Process developed in advance for scale-up

Fast Delivery of Custom Synthesis

Based on profound knowledge and experience in synthesizing core series

Featured Product Series

Cyclopropane Series

Pyrazole & Other Five-Membered Aromatics

Four-membered Aliphatic Ring Series

Pyridine, Pyrimidine & Other Six-Membered Aromatics

Five-membered Aliphatic Ring Series

Indole, Azaindole & Deazapurine Series

Six-membered Aliphatic Ring Series

Other 5,6-Fused Aromatic Series

Bridged, Spiro & Fused Series

Quinoline & Other 6,6-Fused Aromatic Series

Other Series

No.1 Supplier of 18 Core Series


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Process Research & Development

Process R&D Services

Process route establishment

Process optimization

RSM justification studies

Analytical method development

Regulatory filing document preparation

Bulk-scale production of GMP/non-GMP intermediates & RSMs

GLP synthesis for pre-clinical studies

Stability studies

Enabling Technologies

Continuous Flow Technology:Either with fixed bed hydrogenation flow reactor or self-assembled tube reactors, we develop flow process for safe and seamless scale up.

Biocatalysis: From screening, optimization to multi kg scale up, we have experience with lipase, KRED, amidase, ATA etc.

Flow Photochemistry:Scaling up of photoreactions is feasible in PharmaBlock with multiple flow photo reactors.

Fluorination:With large and special equipment to handle fluorination using F2, HF, SF4 etc., we can supply fluorinated material up to metric tons scale.

Pilot Plant and Manufacturing

Why PharmaBlock 

Process developed in advance for core series products

Get started quickly on process R&D with accumulated knowledge and experience of building blocks

Ability to tackle challenging chemistry with enabling technologies

GMP kilo-lab is in planning

GMP compliance

Seamless technology transfer from lab to pilot plant to manufacturing

EHS compliance, QUALITY assurance, IP protection

Manufacturing Sites

Flexible, multi-purpose plants compliant with cGMP and high EHS standards

Able to practice a wide range of chemistry synthesis and enabling technologies

Assets to support preclinical, phase I-III, and commercial-scale need

Seamless process transfer

Audited by a number of global pharmaceutical companies.

Shangyu Site

1,436,000 sq ft

86 reactors from 300-6300L

Pilot and commercial production of non-GMP/GMP intermediates & APIs (in planning)

Diai Site

807,000 sq ft

30 reactors from 200-3000L

Pilot and commercial production of intermediates