PharmaBlock has designed over 10,000 types of Unnatural Amino Acids (UAAs), among which more than 1,300 are available off-the-shelf. Its products cover UAAs with novel structures such as alicyclic, aromatic, linear, bridged and spirocyclic structures, including multiple modification types like N-methyl, α-substituted and F-substituted. PharmaBlock also provides UAAs with different protective groups such as Fmoc, Boc and Cbz, fully meeting diverse structural requirements.

With chemical synthesis and biocatalysis as core pillars, PharmaBlock integrates engineering technologies such as flow chemistry to strongly empower UAAs synthesis. This setup not only responds quickly to the timeline needs of customers’ early-stage projects but also matches the cost control requirements of late-stage projects, facilitating the efficient implementation of projects.

PharmaBlock has completed over 100 kg-scale and more than 30 100-kg-scale production projects, with multiple projects successfully commercialized. It is equipped with sufficient capacity-supporting facilities and has built a comprehensive GMP-compliant production system, comprehensively meeting customer needs from clinical phases to commercialization phases.

PharmaBlock specializes in synthesizing various complex peptide structures such as cyclic peptides and branched peptides. Meanwhile, it offers conjugation services between peptides and molecules like drugs, fluorescent labels and biotin.

Based on customer requirements, PharmaBlock provides custom peptide synthesis services with high purity from milligram to kilogram scale. The purities can reach 98% or higher, catering to the needs of different research phases.

PharmaBlock’s CMC team is composed of senior experts with years of experience in peptide drug development. The team has completed over 30 filing projects and is familiar with domestic and international regulatory requirements, enabling PharmaBlock to provide customers with one-stop CMC solutions from preclinical stages to commercialization.

- Linear Peptides: PharmaBlock covers linear peptides of different lengths, including the synthesis and purification of long-chain peptides.

- Cyclic Peptides: PharmaBlock possesses rich experience in cyclic peptide synthesis, capable of handling multiple structures such as monocyclic, bicyclic and polycyclic peptides.

- Radiopharmaceutical Conjugates (RDC): PharmaBlock has professional capabilities in developing radiopeptide-conjugated prodrugs.

- Other Complex Structures: PharmaBlock can develop various modified peptides such as lipopeptides, glycopeptides and phosphorylated peptides.

- Solid-Phase Peptide Synthesis (SPPS): Suitable for rapid synthesis of most peptides.

- Liquid-Phase Peptide Synthesis (LPPS): Particularly suitable for large-scale production and preparation of peptides with special modifications.

- Enzymatic Peptide Synthesis (EAPS): Environmentally friendly and suitable for the synthesis of peptides with specific structures.

- Continuous Flow Synthesis: Enables high-efficiency and automated production of peptides.